This report displays the potential drug interactions between alprazolam and lithium. Alcohol can increase the nervous system side effects of lithium such as dizziness, drowsiness, and difficulty concentrating. People should avoid or limit the use of alcohol while being treated with lithium. Grapefruit and grapefruit juice may interact with alprazolam and lead to potentially dangerous side effects. Patients should discuss the use of grapefruit products with their doctor and not increase or decrease the amount of grapefruit products in their diet without first talking to their doctor. Additionally, patients should not drink alcohol while taking alprazolam as it can increase the effects of alcohol.
There are four classifications for drug interactions: Major, Moderate, Minor, and Unknown. Major interactions are highly clinically significant and the risk of the interaction outweighs the benefit. Moderate interactions are moderately clinically significant and usually should be avoided or used under special circumstances. Minor interactions are minimally clinically significant and the risk should be minimized or an alternative drug considered. Unknown interactions have no available information.