Uses and Side Effects of Hyaluronidase Injection

Uses and Side Effects of Hyaluronidase Injection

Hylenex: An Overview of Hyaluronidase Injection

What is Hyaluronidase?

Hyaluronidase is a genetically designed protein that is used in combination with fluids injected into the body to treat dehydration. It can also be used as an aid in helping your body absorb other injected medications. Additionally, hyaluronidase is used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

Note that hyaluronidase may also be used for purposes not listed in this medication guide.

Warnings

Serious drug interactions can occur when certain medicines are used together with hyaluronidase. Tell your doctor about all your current medicines.

Before Taking Hyaluronidase

You should not be treated with hyaluronidase if you are allergic to it. Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication. Some medicines can cause unwanted or dangerous effects when used with hyaluronidase. Your doctor may change your treatment plan if you also use:

  • Antibiotics
  • Antidepressants
  • Blood thinners
  • Heart or blood pressure medications
  • Pain or arthritis medicines
  • Sedatives or tranquilizers
  • Tell your doctor if you are pregnant. It may not be safe to breast-feed while using hyaluronidase. Ask your doctor about any risk.

    How is Hyaluronidase Given?

    Hyaluronidase is injected under the skin, into a muscle, or into other tissues of the body. A healthcare provider will give you this injection. Hyaluronidase should not be injected into a vein (as an intravenous injection).

    What Happens if I Miss a Dose?

    Because you will receive hyaluronidase in a clinical setting, you are not likely to miss a dose.

    What Happens if I Overdose?

    Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

    What Should I Avoid After Receiving Hyaluronidase?

    Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

    Hyaluronidase Side Effects

    Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Hyaluronidase may cause serious side effects. Call your doctor at once if you have:

    • Swelling in your hands, feet, or other body areas; or
    • Pain, swelling, itching, or redness where the injection was given.
    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

      What Other Drugs Will Affect Hyaluronidase?

      Other drugs may affect hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

      Frequently Asked Questions

      Further Information

      Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

      Medical Disclaimer

      Copyright 1996-2023 Cerner Multum, Inc. Version: 6.02.

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