Uses and Side Effects of Hylenex Injection

Uses and Side Effects of Hylenex Injection

Overview: Hyaluronidase Injection

Generic name: hyaluronidase

Brand names: Amphadase, Hylenex, Vitrase

Drug class: Miscellaneous uncategorized agents

Hyaluronidase is a genetically designed protein used in combination with fluids injected into the body to treat dehydration. It can also aid in the absorption of other injected medications and help contrast dyes show more clearly on certain types of x-rays or scans. However, serious drug interactions can occur when certain medicines are used together with hyaluronidase, so it’s important to tell your doctor about all your current medicines.


You should not be treated with hyaluronidase if you are allergic to it. Your doctor may perform a skin test to see if you are allergic before administering the medication. Some medicines can cause unwanted or dangerous effects when used with hyaluronidase, so your doctor may change your treatment plan if you also use:

  • Antihistamines
  • Pain or arthritis medicines
  • Medicines to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders
  • Medicines to prevent organ transplant rejection
  • Tell your doctor if you are pregnant, as it may not be safe to breastfeed while using this medicine.

    How is Hyaluronidase Given?

    Hyaluronidase is injected under the skin, into a muscle, or into other tissues of the body by a healthcare provider. It should not be injected into a vein (as an intravenous injection).

    Side Effects

    Get emergency medical help if you have signs of an allergic reaction, such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat. Hylenex may cause serious side effects, including swelling in your hands, feet, or other body areas, or pain, swelling, itching, or redness where the injection was given. This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects.

    What Other Drugs Will Affect Hyaluronidase?

    Other drugs may affect hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.


    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Remember to keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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