Nefazodone, sold under the brand name Serzone, is an antidepressant used to treat major depressive disorder. Unlike other antidepressants, such as SSRIs, tricyclic antidepressants, or MAOIs, nefazodone is not chemically similar to these groups.
Young people taking nefazodone may experience thoughts of suicide. It is important to monitor any changes in mood or symptoms and report them to a doctor. Nefazodone may interact with other drugs and should not be taken if allergic to nefazodone or trazodone or if liver problems have been caused by taking nefazodone.
Before Taking Nefazodone
It is important to inform a doctor of all other medications being taken. Those who have taken an MAO inhibitor must wait at least 14 days before taking nefazodone, and those who have taken nefazodone must wait 7 days before taking an MAOI. Inform a doctor if there is a history of liver problems or if pregnant or breastfeeding. Nefazodone is not approved for use by anyone younger than 18 years old.
How to Take Nefazodone
Follow the prescription label and take the medicine at the same time each day, with or without food. Blood tests may be required to check liver function. Symptoms may not improve for several weeks. Inform a doctor of any planned surgeries. Store at room temperature away from moisture and heat.
Missed Dose and Overdose
If a dose is missed, skip it and take the next dose at the regular time. Do not take two doses at once. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if an overdose is suspected.
Avoiding Side Effects
Avoid drinking alcohol and driving or hazardous activity until the effects of nefazodone are known. Getting up too fast from a sitting or lying position may cause dizziness. Inform a doctor of any new or worsening symptoms, such as mood or behavior changes, anxiety, panic attacks, trouble sleeping, or thoughts of suicide or hurting oneself.
The initial dose for depression is 200 mg orally per day in two divided doses, with a maintenance dose of 300 to 600 mg orally per day. Geriatric patients may have an initial dose of 100 mg orally per day administered in two divided doses, with a maintenance dose of up to 300 to 600 mg orally per day.
Using nefazodone with other drugs that cause drowsiness can worsen this effect. Inform a doctor of all other medications being taken, especially buspirone, digoxin, fluoxetine, propranolol, cholesterol medication, immunosuppressive medicine, or a sedative like Valium.
Nefazodone is an antidepressant used to treat major depressive disorder. It is important to monitor any changes in mood or symptoms and report them to a doctor. Inform a doctor of all other medications being taken and avoid alcohol and hazardous activity until the effects of nefazodone are known.