- Generic name: hyaluronidase (injection) [HYE-al-ure-ON-i-dase]
- What is hyaluronidase?
- Before taking this medicine
- How is hyaluronidase given?
- What happens if I miss a dose?
- What happens if I overdose?
- What should I avoid after receiving hyaluronidase?
- Hyaluronidase side effects
- What other drugs will affect hyaluronidase?
- Frequently asked questions
- More about Vitrase (hyaluronidase)
- Patient resources
- Other brands
- Professional resources
- Related treatment guides
- Further information
- Medical Disclaimer
Generic name: hyaluronidase (injection) [HYE-al-ure-ON-i-dase]
What is hyaluronidase?
Hyaluronidase is a genetically designed protein used together with fluids injected into the body to treat dehydration. It can also be used as an aid in helping your body absorb other injected medications and to help contrast dyes in your body show more clearly on certain types of x-rays or scans. However, hyaluronidase may also be used for purposes not listed in this medication guide.
Serious drug interactions can occur when certain medicines are used together with hyaluronidase. Therefore, it is important to inform your doctor about all your current medicines before taking hyaluronidase.
Before taking this medicine
You should not be treated with hyaluronidase if you are allergic to it. Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication. Additionally, some medicines can cause unwanted or dangerous effects when used with hyaluronidase. Therefore, your doctor may change your treatment plan if you also use:
– insulin or oral diabetes medicine;
– a blood thinner – warfarin, Coumadin, Jantoven;
– any medication that contains epinephrine; or
– any medication that contains a preservative called benzyl alcohol.
Tell your doctor if you are pregnant. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
How is hyaluronidase given?
Hyaluronidase is injected under the skin, into a muscle, or into other tissues of the body. A healthcare provider will give you this injection. However, hyaluronidase should not be injected into a vein (as an intravenous injection).
What happens if I miss a dose?
Because you will receive hyaluronidase in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid after receiving hyaluronidase?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity.
Hyaluronidase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Vitrase may cause serious side effects. Call your doctor at once if you have:
– swelling in your hands, feet, or other body areas; or
– pain, swelling, itching, or redness where the injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect hyaluronidase?
Other drugs may affect hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Therefore, it is important to inform your doctor about all your current medicines and any medicine you start or stop using.
Frequently asked questions
More about Vitrase (hyaluronidase)
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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